Comparative expression analysis of POU4F1, POU4F2 and ISL1 in developing mouse cochleovestibular ganglion neurons.

Highlights: [•] A comparative analysis of the spatiotemporal expression of POU4F1, POU4F2, and ISL1 during mouse inner ear neurogenesis. [•] ISL1 expression starts in the otic epithelium and precedes POU4F1 expression in cochleovestibular ganglion (CVG) neurons. [•] POU4F1 is co-expressed with ISL1 and NEUROD1 in delaminated CVG neurons. [•] POU4F2 expression starts after that of POU4F1 and ISL1, and is expressed in post-mitotic, NEUROD1-negative CVG neurons. [•] The temporal expression order of these transcription factors in mouse CVG neurogenesis is NEUROD1>ISL1>POU4F1>POU4F2. [Copyright &y& Elsevier]