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An interferon-beta promoter reporter assay for high throughput identification of compounds against multiple RNA viruses.

Authors :
Guo, Fang
Zhao, Xuesen
Gill, Tina
Zhou, Yan
Campagna, Matthew
Wang, Lijuan
Liu, Fei
Zhang, Pinghu
DiPaolo, Laura
Du, Yanming
Xu, Xiaodong
Jiang, Dong
Wei, Lai
Cuconati, Andrea
Block, Timothy M.
Guo, Ju-Tao
Chang, Jinhong
Source :
Antiviral Research. Jul2014, Vol. 107, p56-65. 10p.
Publication Year :
2014

Abstract

Highlights: [•] A cell-based IFN-β reporter assay was established for high throughput screen. [•] This assay can be applied to any virus that is able to activate IFN response in the report cells. [•] The assay allows for identification of compounds with antiviral and innate immune response modulating activity. [Copyright &y& Elsevier]

Details

Language :
English
ISSN :
01663542
Volume :
107
Database :
Academic Search Index
Journal :
Antiviral Research
Publication Type :
Academic Journal
Accession number :
96345451
Full Text :
https://doi.org/10.1016/j.antiviral.2014.04.010