Fabrication and investigation of electrochromatographic columns with a simplex configuration.

Highlights: [•] Simplex column configuration with an essentially fully packed bed was introduced. [•] Single particle fritting technology enabled fabrication of robust simplex columns. [•] Simplex column has uniform electric field distribution and higher efficiency. [•] Simplex column configuration should enable regulation of electroseparation speed. [•] Bidirectional electrochromatography was demonstrated using a simplex column. [Copyright &y& Elsevier]