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Treatment of pruritus in early-stage hypopigmented mycosis fungoides with aprepitant.
- Source :
-
Dermatologic Therapy . May2014, Vol. 27 Issue 3, p178-182. 5p. - Publication Year :
- 2014
-
Abstract
- Pruritus is a symptom that significantly affects the patient's quality of life in cutaneous T cell lymphoma ( CTCL). The most effective treatments are those that address the condition itself; however, it is often not possible to control this symptom. Lymphoma-related pruritus normally becomes more severe as CTCL progresses, constituting an important factor for quality of life in these patients. Substance P is a neuromodulator which appears to play a key role in pruritus. Aprepitant is a neurokinin-1 receptor antagonist affecting the substance P receptor. So far, several cases have been documented with an antipruritic response to the drug aprepitant in advanced-stage mycosis fungoides ( MF). In this paper, we describe an excellent response to aprepitant in a female patient with severe pruritus secondary to hypopigmented stage I MF. We would also like to stress the absence of nausea and vomiting of this combined therapy of interferon and aprepitant. Aprepitant could improve tolerance to interferon. [ABSTRACT FROM AUTHOR]
- Subjects :
- *MYCOSIS fungoides
*ITCHING
*QUALITY of life
*ANTINEOPLASTIC agents
*T cells
Subjects
Details
- Language :
- English
- ISSN :
- 13960296
- Volume :
- 27
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Dermatologic Therapy
- Publication Type :
- Academic Journal
- Accession number :
- 96363371
- Full Text :
- https://doi.org/10.1111/dth.12113