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Unraveling the relationship between microbial translocation and systemic immune activation in HIV infection.
- Source :
-
Journal of Clinical Investigation . Jun2014, Vol. 124 Issue 6, p2368-2371. 4p. 1 Color Photograph. - Publication Year :
- 2014
-
Abstract
- Chronic immune activation is a key factor in HIV-1 disease progression. The translocation of microbial products from the intestinal lumen into the systemic circulation occurs during HIV-1 infection and is associated closely with immune activation; however, it has not been determined conclusively whether microbial translocation drives immune activation or occurs as a consequence of HIV-1 infection. In an important study in this issue of the JCI, Kristoff and colleagues describe the role of microbial translocation in producing immune activation in an animal model of HIV-1 infection, SIV infection of pigtailed macaques. Blocking translocation of intestinal bacterial LPS into the circulation dramatically reduced T cell activation and proliferation, production of proinflammatory cytokines, and plasma SIV RNA levels. This study directly demonstrates that microbial translocation promotes the systemic immune activation associated with HIV-1/SIV infection. [ABSTRACT FROM AUTHOR]
- Subjects :
- *HIV infections
*DISEASE progression
*IMMUNE system
*INFECTION
*IMMUNOLOGY
Subjects
Details
- Language :
- English
- ISSN :
- 00219738
- Volume :
- 124
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Journal of Clinical Investigation
- Publication Type :
- Academic Journal
- Accession number :
- 96418988
- Full Text :
- https://doi.org/10.1172/JCI75799