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Effects of hydrochlorothiazide on kidney stone therapy with extracorporeal shock wave lithotripsy.
- Source :
-
Urology Annals . Jul2014, Vol. 6 Issue 3, p208-211. 4p. - Publication Year :
- 2014
-
Abstract
- Objective: The aim of this investigation was to assess the efficacy of hydrochlorothiazide as a hypocalciuric diuretic on stone-free rate of renal pelvic calculi after extracorporeal shock wave lithotripsy (ESWL). Materials and Methods: A double blind, placebo controlled randomized clinical trial was conducted and 52 patients with renal pelvic calculi (diameter ⩽2 cm) were enrolled from February 2010 to September 2010. ESWL protocol was performed by 2,500 shocks per session. The patients were randomized into two groups: (1) 26 patients who were given 25 mg hydrochlorothiazide twice daily; and (2) 26 patients who received placebo. The stone-free rate was defined as residual calculus size ⩽4 mm in controlled ultrasound on 2nd week, 1 month and 3 months after ESWL. Results: 19 (78%) of the first group and 9 (42.9%) of the second group were stone-free after one session of ESWL (P = 0.02). 88% of the group 1 and 47.8% of the group 2 were stone-free on 1 month after ESWL (P = 0.003); however, this effect of hydrochlorothiazide was not related to the patients' body mass index, age and gender. The accessory treatment procedures were applied in 24% of the group 1 compared with 19% of the group 2 during 3 months (P = 0.68). All patients in both groups were stone-free on 3 months following lithotripsy. Conclusions: Hydrochlorothiazide did not impact on the stone free rate and using accessory procedure within 3 months; however, it decreased duration of stone free status and number of ESWL sessions. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09747796
- Volume :
- 6
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Urology Annals
- Publication Type :
- Academic Journal
- Accession number :
- 96540546
- Full Text :
- https://doi.org/10.4103/0974-7796.134261