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A versatile and efficient synthesis of (2S)-2-(hydroxymethyl)-N-Boc-2,3-dihydro-4-pyridone
- Source :
-
Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry . May2003, Vol. 44 Issue 22, p4261. 3p. - Publication Year :
- 2003
-
Abstract
- A versatile and efficient method for the preparation of (2S)-2-(hydroxymethyl)-N-Boc-2,3-dihydro-4-pyridone from l-(−)-phenylalanine 2 utilising the aromatic system as a masked β-keto aldehyde was developed. The key step in the sequence is an intramolecular cyclisation of 6 to give 2,3-dihydropyridin-4-ones. [Copyright &y& Elsevier]
- Subjects :
- *PYRIDONE
*RING formation (Chemistry)
*ORGANIC synthesis
Subjects
Details
- Language :
- English
- ISSN :
- 00404039
- Volume :
- 44
- Issue :
- 22
- Database :
- Academic Search Index
- Journal :
- Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 9655200
- Full Text :
- https://doi.org/10.1016/S0040-4039(03)00888-8