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Etiology of hepatocellular carcinoma influences clinical and pathologic features but not patient survival
- Source :
-
American Journal of Gastroenterology (Springer Nature) . Apr2003, Vol. 98 Issue 4, p907. 8p. - Publication Year :
- 2003
-
Abstract
- : ObjectivesWe investigated the relation between hepatocellular carcinoma (HCC) etiology and biological and clinical parameters indicative of severity of liver disease and/or tumor characteristics and patient survival.: MethodsWe prospectively recruited 384 patients (82.3% male) with first diagnosis of HCC from 1995 to 1998 in Brescia, Italy. Etiology was assessed by interviewing patients regarding their history of alcohol intake and by testing sera for hepatitis B surface antigen and anti-hepatitis C virus (HCV) antibodies and HCV RNA.: ResultsHeavy alcohol intake (>60 g of ethanol per day for at least 1 decade) was found in 33.1% of cases, hepatitis B virus (HBV) infection in 9.4%, HCV in 19.8%, hemochromatosis in 1.3%, alcohol and HBV in 12.0%, alcohol and HCV in 16.1%, HBV and HCV in 3.1%, and no factor in 5.2%. Patients with HBV infection with or without heavy alcohol intake were significantly younger than the others (61.7 vs 64.7 yr, p < 0.001). The proportion of males was significantly higher in patients with heavy alcohol intake alone than in the other patient groups (93.7% vs 77.3%, p < 0.001). Among patients with HCV infection with or without heavy alcohol intake, fewer patients had maximum tumor diameter > 5 cm than the others (12% vs 29.1%, p < 0.001). Eighty patients (20.8%) were alive at the end of follow-up (median survival, 17.7 months), and no differences were observed in survival rates by HCC risk factor.: ConclusionsAlthough some differences were observed in severity of liver disease or tumor characteristics according to etiology, patient survival was not influenced by HCC etiology. [Copyright &y& Elsevier]
- Subjects :
- *LIVER cancer
*ETIOLOGY of diseases
Subjects
Details
- Language :
- English
- ISSN :
- 00029270
- Volume :
- 98
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- American Journal of Gastroenterology (Springer Nature)
- Publication Type :
- Academic Journal
- Accession number :
- 9658112
- Full Text :
- https://doi.org/10.1111/j.1572-0241.2003.t01-1-07289.x