Hepatoprotective coumarins and secoiridoids from Hydrangea paniculata.

Abstract: Three new coumarin glucosides (1, 3, 4), and a new secoiridoid glucoside (2), together with one known secoiridoid glucoside (5), were isolated from the stems of Hydrangea paniculata. Their structures were elucidated on the basis of spectroscopic methods, including extensive NMR, MS and CD spectra. At 10μM, compounds 1–5 showed hepatoprotective activities against DL-galactosamine-induced toxicity in HL-7702 cells. [Copyright &y& Elsevier]