Cytochrome P450-mediated metabolic engineering: current progress and future challenges.

Highlights: [•] P450s catalyze critical steps in all branches of plant specialized metabolism. [•] P450-driven engineering has been successful in both microorganisms and plants. [•] It is not a straightforward process and requires multistep optimizations. [•] Optimizations of the electron and metabolic fluxes are critical aspects. [ABSTRACT FROM AUTHOR]