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Tricyclic and Spirobicyclic Norsesquiterpenes from the Endophytic Fungus Pseudolagarobasidium acaciicola.
- Source :
-
European Journal of Organic Chemistry . Jul2014, Vol. 2014 Issue 19, p3976-3980. 5p. - Publication Year :
- 2014
-
Abstract
- The new tricyclic and spirobicyclic norsesquiterpenes 1 and 2 and the new nor-chamigrane endoperoxide 3, together with the known sesquiterpenes steperoxide A ( 4), merulin B ( 5), and merulin C ( 6), were isolated from the endophytic fungus Pseudolagarobasidium acaciicola. The structures and absolute configurations of 1- 3 were determined by analysis of spectroscopic data, as well as by single-crystal X-ray analysis. Compound 1 has a previously unobserved 6/5/5 fused tricyclic ring system, in which the five-membered (middle) ring is, as revealed by X-ray analysis, perpendicular to a six-membered ring. Compound 2 possesses a hitherto unknown 5/6 fused spirobicyclic ring system. The cytotoxic activities of the isolated compounds 1- 6 were evaluated. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 1434193X
- Volume :
- 2014
- Issue :
- 19
- Database :
- Academic Search Index
- Journal :
- European Journal of Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 96716838
- Full Text :
- https://doi.org/10.1002/ejoc.201402262