New in silico insights into the inhibition of RNAP II by α-amanitin and the protective effect mediated by effective antidotes.

Highlights: [•] α-Amanitin inhibits RNA polymerase II through unknown mechanisms. [•] The interaction of α-amanitin with RNA polymerase II activity is shown in silico. [•] The mechanism relies on binding of α-amanitin to TL and bridge helix residues. [•] Interaction of different antidotes with this enzyme is shown in silico. [ABSTRACT FROM AUTHOR]