Effects of Different Criteria of hCG Administration on IVF/ICSI-ET Outcomes.

Objective:To explore the effects of two criteria of hCG administration on the clinical outcomes of IVF/ICSI -ET. These criteria were individually based on the follicle diameter and the follicle symmetry. Methods: It's a prospective randomized study in our hospital reproductive center. IVF/ICSI-ET patients were randomly divided into two groups from Jan 2013 to Mar 2013. The criterion of hCG administration in Group A was based on the follicle diameter, while Group B on the follicle symmetry. Clinical and laboratory outcomes were then compared. Results: The average days of Gn, serum levels of progesterone and estradiol on the hCG day, the average number of matured eggs, and the rate of matured oocytes of group B were significantly higher than those of group A(P<0.05). There was not significant difference in the numbers of frozen embryos and good quality embryos between the two groups. However, the clinical pregnancy rate of group B was significantly lower than that of group A (42.19% vs. 54.22%, χ²=4.18, P=0.04), and the incidence of OHSS in group B significantly higher than that of group A(10.77% vs. 5.86%, χ²=4.07,P=0.04). Conclusions: The criterion based on the uniform size of follicular is not superior to the traditional criterion focused on the dominant follicle size in the efficacy and safety of IVF/ICSI-ET treatment. [ABSTRACT FROM AUTHOR]