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POSITIVE AND NEGATIVE SELECTION OF T CELLS.
- Source :
-
Annual Review of Immunology . 2003, Vol. 21 Issue 1, p139. 38p. - Publication Year :
- 2003
-
Abstract
- A functional immune system requires the selection of T lymphocytes expressing receptors that are major histocompatibility complex restricted but tolerant to self-antigens. This selection occurs predominantly in the thymus, where lymphocyte precursors first assemble a surface receptor. In this review we summarize the current state of the field regarding the natural ligands and molecular factors required for positive and negative selection and discuss a model for how these disparate outcomes can be signaled via the same receptor. We also discuss emerging data on the selection of regulatory T cells. Such cells require a high-affinity interaction with self-antigens, yet differentiate into regulatory cells instead of being eliminated. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 07320582
- Volume :
- 21
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Annual Review of Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 9688514
- Full Text :
- https://doi.org/10.1146/annurev.immunol.21.120601.141107