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Association Between Serum Fetuin-A levels, Carotid Artery Stiffness, and Intima–Media Thickness in Patients With Normotensive Obstructive Sleep Apnea Syndrome.
- Source :
-
Angiology . Aug2014, Vol. 65 Issue 7, p607-613. 7p. - Publication Year :
- 2014
-
Abstract
- Increased carotid intima–media thickness (cIMT) and stiffness, reflecting subclinical atherosclerosis, are associated with obstructive sleep apnea syndrome (OSAS). The relationship between serum fetuin-A, which inhibits ectopic calcification, and atherosclerosis is unclear. Therefore, we investigated the association between serum fetuin-A levels and carotid artery stiffness and cIMT in patients with normotensive OSAS (n = 50) and non-OSAS controls (n = 38). Compared with controls, there were lower fetuin-A levels (59.4 ± 6.5 vs 68.2 ± 5.8 ng/mL, P = .029), higher mean cIMT (0.73 ± 0.2 vs 0.63 ± 0.3 mm, P < .001), and greater stiffness (β) index (7.45 ± 0.9 vs 5.2 ± 0.7, P = .001) in the OSAS group. The cIMT and stiffness (β) index were inversely correlated with fetuin-A levels (r = −.324, P = .033; r = −.466, P < .001, respectively) and positively correlated with apnea hypopnea index (r = .498, P < .001; r = .422, P = .001, respectively) in the OSAS group. Decreased serum fetuin-A levels were associated with subclinical carotid atherosclerosis in patients with normotensive OSAS. [ABSTRACT FROM PUBLISHER]
- Subjects :
- *AGE distribution
*ALPHA fetoproteins
*CAROTID artery diseases
*CHI-squared test
*STATISTICAL correlation
*ELASTICITY
*ENZYME-linked immunosorbent assay
*REGRESSION analysis
*SLEEP apnea syndromes
*T-test (Statistics)
*U-statistics
*ANKLE brachial index
*DATA analysis software
*DESCRIPTIVE statistics
*CAROTID intima-media thickness
Subjects
Details
- Language :
- English
- ISSN :
- 00033197
- Volume :
- 65
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Angiology
- Publication Type :
- Academic Journal
- Accession number :
- 96920941
- Full Text :
- https://doi.org/10.1177/0003319713497421