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The effects of dendrimer size and central metal ions on photosensitizing properties of dendrimer porphyrins.
- Source :
-
Journal of Drug Targeting . Aug2014, Vol. 22 Issue 7, p610-618. 9p. - Publication Year :
- 2014
-
Abstract
- A series of dendrimer porphyrins (G nDPM; n = generation of dendrimer, n = 1-3; M = coordination metal, M = freebase, Zn, Pt) were prepared and their photosensitizing properties were compared. All G nDPM exhibited sharp absorption in organic solvents. However, the Soret absorptions of G nDPM(CO2H) in 10 mM phosphate buffer solution (pH = 7.4) are broader than those of G nDPM in organic solvents, indicating inhomogeneous microenvironments of the focal porphyrin derivatives. All G3DPM(CO2H) successfully formed globular polyion complex micelles that were uniform in size. Under dark conditions, all G nDPM(CO2H) showed negligible cytotoxicity. However, all samples exhibited concentration-dependent photocytotoxicity under light irradiation. In vitro photocytotoxicity as well as singlet oxygen generation revealed that G3DPZn(CO2H) is the best dendritic PS of the three different dendrimer porphyrin species. [ABSTRACT FROM AUTHOR]
- Subjects :
- *DENDRIMERS
*PORPHYRINS
*DRUG delivery systems
*DRUG therapy
*ANTINEOPLASTIC agents
Subjects
Details
- Language :
- English
- ISSN :
- 1061186X
- Volume :
- 22
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Journal of Drug Targeting
- Publication Type :
- Academic Journal
- Accession number :
- 97012200
- Full Text :
- https://doi.org/10.3109/1061186X.2014.928717