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External validity of a population-based study on osteoporosis and fracture.
- Source :
-
Acta Orthopaedica . Aug2014, Vol. 85 Issue 4, p433-437. 5p. 1 Chart, 2 Graphs. - Publication Year :
- 2014
-
Abstract
- Background and purpose - Little is known about the characteristics of non-participants in epidemiological studies. We evaluated external validity by comparing fracture and mortality rate in participants and non-participants in a longitudinal study on risk factors for fracture. Methods - 1,604 randomly selected women, 75 years of age, were invited to attend a study on osteoporosis and fracture. 1,044 women attended the study (participants) and 560 women did not participate (non-participants). Fracture data for all were obtained prospectively from radiographic records. Mortality data were obtained through the population register. Mean follow-up was 13 (11-15) years. Cumulative survival was compared with the log-rank test. Fracture incidence rates per 1,000 person-years were compared with Mann-Whitney U-tests. In addition, fracture comparisons were made with the cumulative incidence function and Gray's test. Results - 454 participants (44%) died during the follow-up, as compared to 372 of the non-participants (66%) (p < 0.001). The fracture incidence rate for any type of fracture was 43 for participants and 47 for non-participants (p = 1.0). The fracture incidence rate for typical osteoporotic fracture was 36 for participants and 39 for non-participants (p = 0.6). The corresponding values for distal forearm fracture were 11 and 7 (p = 0.002), they were 8 and 9 for proximal humerus fracture (p = 0.9), 13 and 10 for vertebral fracture (p = 0.007), 15 and 18 for hip fracture (p = 0.8), and they were 6 and 5 for pelvic fracture (p = 0.3). The cumulative incidence function confirmed the results. Interpretation - Our findings suggest that participants had a lower mortality rate than non-participants. Distal forearm and vertebral fractures were more frequent in participants. However, the external validity for fractures in general appeared to be satisfactory. [ABSTRACT FROM AUTHOR]
- Subjects :
- *RISK factors of fractures
*LONGITUDINAL method
*MORTALITY
*OSTEOPOROSIS
*RESEARCH funding
*STATISTICAL sampling
*SURVIVAL analysis (Biometry)
*U-statistics
*CONTROL groups
*DATA analysis software
*DESCRIPTIVE statistics
*KAPLAN-Meier estimator
*LOG-rank test
*DISEASE complications
RESEARCH evaluation
Subjects
Details
- Language :
- English
- ISSN :
- 17453674
- Volume :
- 85
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Acta Orthopaedica
- Publication Type :
- Academic Journal
- Accession number :
- 97028940
- Full Text :
- https://doi.org/10.3109/17453674.2014.920987