Unraveling principles of lead discovery: From unfrustrated energy landscapes to novel molecular...

Authors :: Rejto, Paul A.
Verkhivker, Gennady M.
Source :: Proceedings of the National Academy of Sciences of the United States of America. 8/20/96, Vol. 93 Issue 17, p8945. 6p. 3 Color Photographs, 1 Diagram, 2 Charts, 9 Graphs.
Publication Year :: 1996
Abstract: Introduces a new computational method based on the primary recognition event in the protein binding site. Thermodynamic requirement of relative kinetic accessibility; Identification of core fragments responsible for primary recognition by the FK506 binding protein.

Language :: English
ISSN :: 00278424
Volume :: 93
Issue :: 17
Database :: Academic Search Index
Journal :: Proceedings of the National Academy of Sciences of the United States of America
Publication Type :: Academic Journal
Accession number :: 9703202608
Full Text :: https://doi.org/10.1073/pnas.93.17.8945

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