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Conversion of N-benzyloxycarbonylamino- and N-tosylamino-benzyl phenylsulfones by green Strecker reactions to α-aminobenzyl nitriles using potassium hexacyanoferrate(II).
- Source :
-
Journal of Chemical Research . Jul2014, Vol. 38 Issue 7, p432-436. 5p. - Publication Year :
- 2014
-
Abstract
- The cyanation of aldimines, generated in situ from N-benzyloxycarbonylamino- and N-tosylamino-benzyl phenylsulfones, to the corresponding N-protected α-aminobenzyl nitriles has been achieved by eco-friendly Strecker reactions using potassium hexacyanoferrate(II) as a cyanide source, benzoyl chloride as a promoter, and potassium hydroxide as a base. The protocol has the advantages of using a nontoxic, nonvolatile and inexpensive cyanating agent, employing a simple work-up procedure and producing high yields. [ABSTRACT FROM AUTHOR]
- Subjects :
- *SULFONES
*NITRILES
*POTASSIUM hydroxide
*ALDIMINES
*CYANIDES
Subjects
Details
- Language :
- English
- ISSN :
- 17475198
- Volume :
- 38
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Journal of Chemical Research
- Publication Type :
- Academic Journal
- Accession number :
- 97084841
- Full Text :
- https://doi.org/10.3184/174751914X14030207593683