Prion (PrPSc)-specific epitope defined by a monoclonal antibody.

Presents research which described a monoclonal antibody, 15B3, that can discriminate between the normal and disease-specific forms of the prion protein (PrP). What prions are; Isoform of prion protein; Importance of research; 15B3 precipitating bovine, murine or human PrPSc; Use of immobilized synthetic peptides; NMR structure of recombinant mouse PrP; Models for PrPSc-specific epitope.