Back to Search Start Over

A structural perspective of compensatory evolution.

Authors :
Ivankov, Dmitry N.
Finkelstein, Alexei V.
Kondrashov, Fyodor A.
Source :
Current Opinion in Structural Biology. Jun2014, Vol. 26, p104-112. 9p.
Publication Year :
2014

Abstract

The study of molecular evolution is important because it reveals how protein functions emerge and evolve. Recently, several types of studies indicated that substitutions in molecular evolution occur in a compensatory manner, whereby the occurrence of a substitution depends on the amino acid residues at other sites. However, a molecular or structural basis behind the compensation often remains obscure. Here, we review studies on the interface of structural biology and molecular evolution that revealed novel aspects of compensatory evolution. In many cases structural studies benefit from evolutionary data while structural data often add a functional dimension to the study of molecular evolution. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
0959440X
Volume :
26
Database :
Academic Search Index
Journal :
Current Opinion in Structural Biology
Publication Type :
Academic Journal
Accession number :
97417964
Full Text :
https://doi.org/10.1016/j.sbi.2014.05.004