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Seco-pregnane steroidal glycosides from the roots ofCynanchum atratum and their anti-TMV activity.
- Source :
-
Fitoterapia . Sep2014, Vol. 97, p50-63. 14p. - Publication Year :
- 2014
-
Abstract
- Fifteen new seco-pregnane steroidal glycosides cynanosides A-O (1-15) together with twenty-seven known ones were isolated from the roots of Cynanchum atratum. The structures of 1-15 were determined by extensive analysis of spectroscopic data. The anti-tobacco mosaic virus (TMV) activity of these steroidal glycosides was screened by the conventional half-leaf method, enzyme-linked immunosorbent assay, and Western blot methods, most of them showed potent anti-TMV activity. Among them, compounds 1, 7, 13, 28 and 31 showed significantly anti-TMV activity with an IC50 value of 20.5, 18.6, 22.0, 19.2 and 22.2 μg/mL, respectively, and were much more effective than the positive control, ningnanmycin (IC50 = 49.6 μg/mL). [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0367326X
- Volume :
- 97
- Database :
- Academic Search Index
- Journal :
- Fitoterapia
- Publication Type :
- Academic Journal
- Accession number :
- 97422295
- Full Text :
- https://doi.org/10.1016/j.fitote.2014.03.027