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Interleukin-25 Enhances Allergic Inflammation through p38MAPK and NF-κB Pathways in Mouse Models of Allergic Rhinitis.
- Source :
-
Iranian Journal of Allergy, Asthma & Immunology . Dec2014, Vol. 13 Issue 6, p412-419. 8p. - Publication Year :
- 2014
-
Abstract
- Interleukin (IL)-25, a cytokine of IL-17 family, can activate p38 Mitogen-Activated Protein kinases(MAPK) and Nuclear Factor(NF)-'B pathways to propagate Th2 responses. The allergic rhinitis mouse model was established by stimulating BALB/c mouse with ovalbumin (OVA). Then we detected expression of IL-25 and downstream p38MAPK and NF-'B. The expression of IL-25, p38MAPK and NF-'B were detected in the OVA-induced allergic rhinitis mouse model. The allergic parameters, such as allergic symptoms, serum OVA-specific immunoglobulin E (IgE) levels and eosinophil infiltration in the nasal mucosa were compared between OVA group and control group. OVA-induced mice displayed significantly higher allergic responses compared with the saline control group. OVA induced mice demonstrated more allergic symptoms, higher serum OVA-specific IgE levels and eosinophil infiltrations. The increased expression of IL- 25, p38MAPK and NF-'B immunoreactivity were detected in epidermal cells in the OVA group. The mRNA measurement of IL-25, p38MAPK and NF-'B showed the same result. IL-25 enhances the OVA-induced allergic rhinitis by activating p38MAPK and NF-'B pathways. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 17351502
- Volume :
- 13
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Iranian Journal of Allergy, Asthma & Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 97422438