Pemfigoid pęcherzowy u pacjentki z erytrodermią łuszczycową sprowokowany miejscowym zastosowaniem altacetu.

Introduction. Psoriasis is a chronic, inflammatory and proliferative skin diseasewith a complex pathogenesis. Associations between psoriasis and various systemic and skin disorders have been reported. In the literature, there are also a few reports of coexistence of bullous pemphigoid with psoriasis. Objective. The aimof this paper was to present a patient with psoriasis, inwhom, after topical application of altacet (aluminumacetotartrate) bullous pemphigoid developed. Case report.We present a case of 63-year-old patient with 4-month history of psoriasis, inwhomafter chronic topical treatmentwith high-potency corticosteroids, exacerbation of skin lesions with tendency to erythroderma occured. During the hospitalization generalized inflammation of the skin and appearance of numerous pustules were observed. Laboratory tests revealed increase in concentrations ofmarkers of inflammation. Oral antibiotic and neutral moisturizing topical treatment were administered. In the following days swelling of the dorsa of the hands and feet were observed onwhich compresseswith altacet were applied. The next day tense blisters were observed, initially on the skin of the hands and feet, then on the trunk and upper and lower extremities. Immunological test of serumconfirmed the diagnosis of bullous pemphigoid. After systemic (antibiotic and acitretin) and topical treatment receding of skin lesions was observed. Conclusions. In the presented case chronic topical glicocorticosteroid therapy caused erythrodermic formof psoriasis. Due to the swelling of hands and feet compressess with altacet were applied which provoked bullous pemphigoid, confirmed immunologically. Pathogenetic link between this two diseases remains unclear. Coexistence of psoriasis and pemphigoid may cause the therapeutic difficulties and requires careful therapeutic approach. [ABSTRACT FROM AUTHOR]