Studies on PPAR α and γ participating in progression of liver fibrosis by regulating ACSL1.

During the development and procession of liver fibrosis, peroxisome proliferator - activated receptor (PPAR) &$945; and γ are in charge of the regulation of lipid metabolism, fatty acid metabolism, anti - liver fibrosis, etc., and are closely related to fat metabolism - related enzymes. As a key enzyme in fat metabolism, acyl - CoA synthetase long - chain family member 1 (ACSL1) is involved in lipid synthesis and catabolism and then causes lipid deposition and inflammation in the liver, so it directly or indirectly promotes hepatic fibrosis. The biological functions and roles of PPAR α and γ and ACSL1 are reviewed ; the action mechanisms of PPAR a and Y in the transcriptional regulation of ACSL1 are briefly described ; the regulatory effects of PPAR a and Y on ACSL1 and their effects on the progression of hepatic fibrosis are analyzed from the aspects of liver lipid metabolism and hepatic stellate cell activation. It is pointed out that in the liver PPAR a and γ are directly or indirectly involved in the progression of hepatic fibrosis by regulating ACSL1. [ABSTRACT FROM AUTHOR]