Catalytic Asymmetric Assembly of C3-MonosubstitutedChiral Carbazolones and Concise Formal Synthesis of (−)-Aspidofractinine:Application of Enantioselective Pd-Catalyzed Decarboxylative Protonationof Carbazolones.

Thefirst method for the asymmetric synthesis of C3-monosubstitutedchiral carbazolones, structural motifs common in medicinal chemistry,has been achieved using Pd-catalyzed decarboxylative protonation ofcarbazolones. This methodology has been applied to the first catalyticenantioselective formal synthesis of (−)-aspidofractinine withstep economy and simplicity. [ABSTRACT FROM AUTHOR]