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Synthesis, characterization, molecular modelling and.
- Source :
-
Applied Organometallic Chemistry . Sep2014, Vol. 28 Issue 9, p712-719. 8p. - Publication Year :
- 2014
-
Abstract
- A new series of Cu2+, Pt4+, Pd2+, Au3+ and Nd3+ complexes derived from 2-(pyridin-1-ium-1-yl) acetate have been synthesized and characterized using elemental analyses, spectral (infrared (IR), UV-visible, mass, 13C NMR and 1H NMR), magnetic and thermal measurements. IR results suggest that the ligand acts in a neutral monodentate fashion in all complexes. Octahedral geometry is proposed for Cu2+ and Pt4+ complexes and square-planar for Pd2+ and Au3+ complexes. The bond lengths, bond angles, and HOMO and LUMO were calculated. Superoxide dismutase-like radical scavenger activity and cytotoxic activity of the isolated complexes on HepG2 liver cancer cells have been screened. Ligand and complexes (Pt4+ and Nd3+) exhibit potent antioxidant activity upon coordination while Cu2+ and Au3+ complexes do not show superoxide dismutase-like radical scavenger activity. The cytotoxic activity assay against HepG2 cell line proves that the ligand and its Pt4+ complex have a high cytotoxic activity, while the other complexes showed no cytotoxic activity. Copyright © 2014 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 02682605
- Volume :
- 28
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Applied Organometallic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 97546121
- Full Text :
- https://doi.org/10.1002/aoc.3187