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Correlation between both Morphologic and Functional Changes and Anxiety in Alzheimer's Disease.
- Source :
-
Dementia & Geriatric Cognitive Disorders . Aug2014, Vol. 38 Issue 3/4, p153-160. 8p. 4 Charts, 2 Graphs. - Publication Year :
- 2014
-
Abstract
- Introduction: Although anxiety symptoms are often observed in Alzheimer's disease (AD), little attention has been paid to this symptom compared with other neuropsychiatric symptoms. Methods: Twenty-six patients with mild AD underwent both magnetic resonance imaging and single photon emission tomography with technetium-99m ethyl cysteinate dimer. Neuropsychiatric symptoms were evaluated using the Behavioral Pathology in Alzheimer's Disease Scale (Behave-AD). We investigated the relationship between anxiety and neuroimaging using Statistical Parametric Mapping 8 software. Results: The Behave-AD anxiety score was correlated with hyperperfusion in the bilateral anterior cingulate cortices and a reduction in the gray matter volume in the right precuneus and inferior parietal lobule. Conclusion: Our results suggest that anxiety in AD could overlap with the neural correlates of anxiety disorders, and that the specific degeneration associated with AD might be associated with anxiety. © 2014 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
- Subjects :
- *BRAIN
*RADIOGRAPHY
*ALZHEIMER'S disease
*ANXIETY
*INTERVIEWING
*MAGNETIC resonance imaging
*NEUROPSYCHOLOGICAL tests
*RESEARCH methodology
*NEURORADIOLOGY
*RESEARCH funding
*STATISTICS
*DATA analysis
*MULTIPLE regression analysis
*SINGLE-photon emission computed tomography
*DATA analysis software
Subjects
Details
- Language :
- English
- ISSN :
- 14208008
- Volume :
- 38
- Issue :
- 3/4
- Database :
- Academic Search Index
- Journal :
- Dementia & Geriatric Cognitive Disorders
- Publication Type :
- Academic Journal
- Accession number :
- 97552845
- Full Text :
- https://doi.org/10.1159/000358822