Antioxidant and anti-inflammatory caffeoyl phenylpropanoid and secoiridoid glycosides from Jasminum nervosum stems, a Chinese folk medicine.

Eight compounds including four caffeoyl phenylpropanoid glycosides, jasnervosides A–D ( 1 – 4 ), one monoterpenoid glycoside, jasnervoside E ( 5 ), and three secoiridoid glycosides, jasnervosides F–H ( 10 – 12 ), were isolated from the stems of Jasminum nervosum Lour. (Oleaceae), along with four known compounds, poliumoside ( 6 ), verbascoside ( 7 ), α- l -rhamnopyranosyl-(1→3)- O -(α- l -rhamnopyranosyl(1→6)-1- O - E -caffeoyl-β- d -glucopyranoside ( 8 ), and jaspolyanthoside ( 9 ). Their structures were elucidated on the basis of their physicochemical and spectroscopic properties. Compounds 1 , 2 , 4 and 11 displayed potent antioxidant activities in the DPPH assay, while 2 and 3 displayed good activities against LPS-induced TNF-α and IL-1β production in BV2 cells. Compounds 1 – 5 and 10 – 12 were evaluated for their cytotoxic activities against three human cancer cell lines (A-549, Bel-7402, and HCT-8), but none displayed significant activity. [ABSTRACT FROM AUTHOR]