The effect of nC60 on tissue distribution of ibuprofen in Cyprinus carpio.

The potential transfer of fullerene aqueous suspension (nC 60 ) associated contaminants in vivo is one of the most significant and currently not well-understood environmental risks. In this study, the carrier function of nC 60 for ibuprofen (IBU) was examined through whole-body and tissue distribution determination of nC 60 and IBU in Cyprinus carpio . The results showed that the presence of nC 60 only slightly increased the whole-body burden of IBU, because the amount of soluble IBU far exceeds that of nC 60 associated form of IBU; while the presence of nC 60 activated the catalase activity and enhanced the lipid peroxidation in the liver, suggesting an obviously induced oxidative damage to fish. With the presence of nC 60 , the uptake of IBU in both gill and digestive tract tissues increased obviously: the uptake of IBU in the gill was mainly from the desorption of nC 60 associated IBU, and that in the digestive tract was both from nC 60 associated IBU and soluble IBU. On the contrary, the nC 60 reduced IBU uptake in the brain, probably due to the high accumulation of nC 60 which blocked the blood brain barrier. Moreover, there was no significant increase in the muscle, which implies that the soluble form should be the main source of IBU accumulation in the muscle. The carrier function of nC 60 observed in the present study indicates the potential transportation of other contaminants and the subsequently enhanced environmental risks. Capsule Fullerene aqueous suspension functioned as a carrier to alter the tissue distribution of ibuprofen in Cyprinus carpio . [ABSTRACT FROM AUTHOR]