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SUMO1 Genetic Polymorphisms May Contribute to the Risk of Nonsyndromic Cleft Lip With or Without Palate: A Meta-Analysis.
- Source :
-
Genetic Testing & Molecular Biomarkers . Sep2014, Vol. 18 Issue 9, p616-624. 9p. - Publication Year :
- 2014
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Abstract
- Objective: We conducted the present meta-analysis to investigate whether single-nucleotide polymorphisms (SNPs) in the SUMO1 gene contribute to the risk of nonsyndromic cleft lip with or without palate (NSCL/P). Method: The Web of Science (1945-2013), the Cochrane Library Database (Issue 12, 2013), PubMed (1966-2013), EMBASE (1980-2013), CINAHL (1982-2013), and the Chinese Biomedical Database (CBM) (1982-2013) were searched without language restrictions. Meta-analysis was performed with the use of the STATA statistical software. Results: Six studies with a total of 1381 NSCL/P patients and 2054 control subjects were included. Twenty-seven functional polymorphisms in the SUMO1 gene were assessed. Our results indicated that SUMO1 genetic polymorphisms were correlated with an increased risk of NSCL/P. Subgroup analysis by the SNP type indicated that 4 functional polymorphisms (rs12470401 T>C, rs16838917 A>G, rs12470529 A>G, and rs7572505 A>G) in the SUMO1 gene might be strongly correlated with NSCL/P risk. Furthermore, ethnicity-stratified analysis demonstrated that SUMO1 genetic polymorphisms were closely related to an increased risk of NSCL/P among both Asians and Caucasians. Conclusion: Our findings provide empirical evidence that SUMO1 genetic polymorphisms might be strongly involved in the etiology of NSCL/P, especially for rs12470401 T>C, rs16838917 A>G, rs12470529 A>G, and rs7572505 A>G polymorphisms. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 19450265
- Volume :
- 18
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Genetic Testing & Molecular Biomarkers
- Publication Type :
- Academic Journal
- Accession number :
- 97873676
- Full Text :
- https://doi.org/10.1089/gtmb.2014.0056