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Global chemokine expression in methylmercury-treated mice: methylmercury induces brain-specific expression of CCL3 and CCL4.
- Source :
-
Journal of Toxicological Sciences . Dec2013, Vol. 38 Issue 6, p925-929. 5p. - Publication Year :
- 2013
-
Abstract
- We previously reported that methylmercury induces brain-specific upregulation of a chemokine gene, the CCL4 gene. In this study, we investigated the changes in gene expression levels of all chemokines in various tissues (cerebellum, cerebrum, kidney, liver, and spleen) of methylmercury-treated mice. We found that methylmercury induced upregulation of the CCL4 gene and the CCL3 gene, in a brain-specific manner. This finding suggests that upregulation of these two chemokine genes mediates selective damage by methylmercury in the central nervous system. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03881350
- Volume :
- 38
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Journal of Toxicological Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 98123405
- Full Text :
- https://doi.org/10.2131/jts.38.925