Chemoselective synthesis of quinoxalines and benzimidazoles by silica gel catalysis.

Authors :: Li, Chunmei
Zhang, Furen
Yang, Zhen
Qi, Chenze
Source :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. Oct2014, Vol. 55 Issue 40, p5430-5433. 4p.
Publication Year :: 2014
Abstract: Treatment of nitroolefins and o -phenylenediamine with silica gel catalyst produced quinoxalines mainly in THF, but gave benzimidazoles efficiently in water. Such a solvent-dependent chemoselective reaction has prominent features of affording two cyclized products selectively with the same substrate, short reaction time, operational simplicity, as well as available starting materials and nontoxic catalysts. In addition, the scope and limitations were explored and a plausible reaction mechanism is proposed. [ABSTRACT FROM AUTHOR]

Subjects :: *CHEMOSELECTIVITY
*QUINOXALINES
*BENZIMIDAZOLES
*SILICA gel
*CATALYSIS
*SOLVENTS

Language :: English
ISSN :: 00404039
Volume :: 55
Issue :: 40
Database :: Academic Search Index
Journal :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
Publication Type :: Academic Journal
Accession number :: 98140294
Full Text :: https://doi.org/10.1016/j.tetlet.2014.08.022

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