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Chemoselective synthesis of quinoxalines and benzimidazoles by silica gel catalysis.
- Source :
-
Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry . Oct2014, Vol. 55 Issue 40, p5430-5433. 4p. - Publication Year :
- 2014
-
Abstract
- Treatment of nitroolefins and o -phenylenediamine with silica gel catalyst produced quinoxalines mainly in THF, but gave benzimidazoles efficiently in water. Such a solvent-dependent chemoselective reaction has prominent features of affording two cyclized products selectively with the same substrate, short reaction time, operational simplicity, as well as available starting materials and nontoxic catalysts. In addition, the scope and limitations were explored and a plausible reaction mechanism is proposed. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CHEMOSELECTIVITY
*QUINOXALINES
*BENZIMIDAZOLES
*SILICA gel
*CATALYSIS
*SOLVENTS
Subjects
Details
- Language :
- English
- ISSN :
- 00404039
- Volume :
- 55
- Issue :
- 40
- Database :
- Academic Search Index
- Journal :
- Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 98140294
- Full Text :
- https://doi.org/10.1016/j.tetlet.2014.08.022