Back to Search
Start Over
Cobalt-Catalyzed, Aminoquinoline-Directed Couplingof sp2C–H Bonds with Alkenes.
- Source :
-
Organic Letters . Sep2014, Vol. 16 Issue 17, p4684-4687. 4p. - Publication Year :
- 2014
-
Abstract
- A methodfor cobalt-catalyzed, aminoquinoline-directed ortho-functionalization of sp2C–H bondswith alkenes has been developed. Reactions proceed at room temperaturein trifluoroethanol solvent, use oxygen from air as an oxidant, andrequire Mn(OAc)3as a cocatalyst. Benzoic, heteroaromatic,and acrylic acid aminoquinoline amides react with ethylene as wellas mono- and disubstituted alkenes affording products in good yields.Excellent functional group tolerance is observed; halogen, nitro,ether, and unprotected alcohol functionalities are compatible withthe reaction conditions. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15237060
- Volume :
- 16
- Issue :
- 17
- Database :
- Academic Search Index
- Journal :
- Organic Letters
- Publication Type :
- Academic Journal
- Accession number :
- 98249578
- Full Text :
- https://doi.org/10.1021/ol502005g