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Multidrug-Resistance 1 Gene Single-Nucleotide Polymorphisms Do Not Influence Long-Term Graft Survival After Kidney Transplantation.

Authors :
Saracino, A.
Muscaridola, N.
Cifarelli, R.A.
Stallone, G.
Grandaliano, G.
Santarsia, G.
Source :
Transplantation Proceedings. Sep2014, Vol. 46 Issue 7, p2214-2219. 6p.
Publication Year :
2014

Abstract

Background The single-nucleotide polymorphisms (SNPs) of the Multidrug resistance 1 (MDR1) gene have been associated with changes in the pharmacokinetics of cyclosporine (CsA) and tacrolimus (FK506). Our aim was investigate the influence of MDR1 SNPs on long-term graft survival in a population of kidney transplant recipients. Methods We retrospectively analyzed 154 patients; they were genotyped for the SNPs C1236T, G2677T/A, and C3435T and evaluated for the influence of those 3 SNPs on CsA or FK506 pharmacokinetics and on long-term graft survival. Results Thirty-one patients were wild-type for C1236T, G2677T/A, and C3435T polymorphisms (group A), 76 patients had ≥1 heterozygous mutations (group B), and 47 patients had ≥1 homozygous mutations (group C). CsA-receiving patients in group C needed a significantly higher oral dose than patients in groups B and A ( P = .02). No differences in FK506 trough level nor in oral dose taken were observed in FK506-receiving patients. Kaplan-Meier analysis did not show survival differences in the 3 groups, and Cox proportional hazards model confirmed that the MDR1 SNPs did not represent a risk for graft loss. Conclusions Pretransplantation determination of MDR1 SNPs may be helpful to optimize the starting dose of CsA but can not predict long-term graft survival. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00411345
Volume :
46
Issue :
7
Database :
Academic Search Index
Journal :
Transplantation Proceedings
Publication Type :
Academic Journal
Accession number :
98479065
Full Text :
https://doi.org/10.1016/j.transproceed.2014.07.051