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Ritonavir-Induced Hepatotoxicity and Ultrastructural Changes of Hepatocytes.
- Source :
-
Ultrastructural Pathology . Oct2014, Vol. 38 Issue 5, p329-334. 6p. - Publication Year :
- 2014
-
Abstract
- To investigate the effect of ritonavir on hepatocyte proliferation, we detected the change of cleaved caspase-3 expression level in the hepatocytes. Furthermore, the morphological and ultrastructural changes of hepatocytes derived from RTV-treated mice have been observed. The results showed that ritonavir can evidently inhibit hepatocyte proliferation and increase cleaved caspase-3 expression level. Under the electron microscope, chromatin margination, mitochondrial cristae disappearance, karyopyknosis and cytoplasmic vacuolization can be observed in the hepatocytes of mice treated with ritonavir. In conclusion, the mechanism of ritonavir's hepatotoxicity is that it induces apoptosis of hepatocytes via the caspase-cascade system. [ABSTRACT FROM AUTHOR]
- Subjects :
- *RITONAVIR
*HEPATOTOXICOLOGY
*LIVER cells
*CASPASES
*CYSTEINE proteinases
Subjects
Details
- Language :
- English
- ISSN :
- 01913123
- Volume :
- 38
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Ultrastructural Pathology
- Publication Type :
- Academic Journal
- Accession number :
- 98487663
- Full Text :
- https://doi.org/10.3109/01913123.2014.914114