Chemical Constituents of Metabolites Produced by the Actinomycete Acrocarpospora punica.

One new γ-butyrolactone derivative, acrocarpunilactone ( 1), was isolated and identified from the rice solidsubstrate fermentation culture of an actinomycete, Acrocarpospora punica, together with nine known compounds, hydroxychavicol acetate ( 2), 4-allylcatechol ( 3), trans-caffeic aldehyde ( 4), (-)-ent-4β-hydroxy-10α-methoxyaromadendrane ( 5), (6α,7α)-4β-hydroxy-10α-methoxyaromadendrane ( 6), futoamide ( 7), N-[8′-(4′-hydroxyphenylethyl)]-2-hydroxybenzoylamide ( 8), hemiariensin ( 9), and 3-ethyl-4-hydroxybenzoic acid ( 10). Furthermore, the inhibitory effects of some isolates (compounds 1- 6) on nitric oxide (NO) production in lipopolysaccharide (LPS)-activated macrophages were also evaluated. Compounds 1- 3 showed stronger inhibition on NO production than the positive control quercetin. [ABSTRACT FROM AUTHOR]