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Does urinary incontinence have fetal origins? Results from a nationwide twin study.
- Source :
-
International Urogynecology Journal . Nov2014, Vol. 25 Issue 11, p1471-1477. 7p. - Publication Year :
- 2014
-
Abstract
- Introduction and hypothesis: The aim of this study is to evaluate the effect of birth weight and being born small for gestational age (SGA) on urinary incontinence (UI) among premenopausal women. Methods: In 2005, a total of 14,094 female twins born 1959-1985 who had been included in the Swedish Twin Registry participated in a survey on common exposures and complex diseases, including urinary incontinence. Information regarding birth weight and gestational age was obtained from the Medical Birth Register (for twins born 1973-1985) and from the medical archives (for twins born 1959-1972). A logistic regression model based on generalized estimating equations was used to estimate odds ratios (ORs) with 95 % confidence intervals (CIs). Results: In both crude and adjusted analysis, birth weight and SGA had no effect on UI. An interaction between low birth weight (<2,500 g) and body mass index (BMI) later in life was found for overall and stress UI. Compared with women who were not overweight and had a birth weight above 2,500 g, overweight women (BMI ≥ 25) who had a normal birth weight had a 35 % higher odds of incontinence , while overweight women who had a low birth weight had an approximately 85 % higher odds of UI (OR = 1.84, 95 % CI 1.39-2.45 for overall UI; OR = 1.83, 95 % CI 1.35-2.48 for stress UI). Conclusions: Birth weight and SGA had no direct effect on urinary incontinence; however, low birth weight in combination with an elevated adult BMI may contribute to the risk of urinary incontinence later in life. [ABSTRACT FROM AUTHOR]
- Subjects :
- *BIRTH weight
*GESTATIONAL age
*URINARY incontinence
*PERIMENOPAUSE
*BODY mass index
Subjects
Details
- Language :
- English
- ISSN :
- 09373462
- Volume :
- 25
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- International Urogynecology Journal
- Publication Type :
- Academic Journal
- Accession number :
- 98742783
- Full Text :
- https://doi.org/10.1007/s00192-014-2399-5