Synthesis and evaluation of α-, β-glucosidase inhibition of 1-N-carboxamide-1-azafagomines and 5-epi-1-azafagomines.

1- N -Carboxamide 1-azafagomines and 5- epi -1-azafagomines were obtained from 1-azafagomine and 5- epi -1-azafagomine. The hydroxyl groups and the N -2 pyridazine position were protected prior to reaction with different isocyanates to form ureas. Protective groups were removed leading to the target compounds in 18–23% global yields. Final compounds were tested towards α- and β-glucosidases. [ABSTRACT FROM AUTHOR]