A convenient synthesis of novel aza-C-disaccharide analogues.

Novel aza- C -disaccharide analogues have been conveniently synthesized by using the isoxazoline-linked C -disaccharide derivatives as the intermediates. Firstly, the C N of isoxazoline was reduced to C–N by using DIBAL-H as reducing agent, then followed by the tandem multi-step reactions through catalytic hydrogenation with Pd(OH) 2 /C involving debenzylated, reductive cleavage of the N–O, condensation–cyclization of the aldehyde and the in situ generated amine group to form imine C N and then C N hydrogenation to form C–N, thus providing a practical and new access to the synthesis of novel aza- C -disaccharide analogues. [ABSTRACT FROM AUTHOR]