Klivaj Evresi ve Blastokist Embriyo Transferlerinin Over Rezervine Göre Karşılaştırılması.

Background: To compare the pregnancy rates of patients experiencing cleavage stage versus blastocyst single embryo transfer (ET) with regard to ovarian reserve. Methods: This study was conducted with analysis of 200 ICSIET cycles performed in our IVF Center. A total of 78 ICSI- ET cycles down-regulated with GnRH antagonists were included in the study and the etiology of infertility was as follows: tubal factor (n=8), decreased ovarian reserve (n=29), and unexplained infertility (n=41). The population was divided into two groups according to the number of retrieved oocytes (NRO). The groups were compared for the parameters of ET day, embryo quality, grade1 embryo rate, pregnancy rate and implantation rate. Results: The 78 women were divided into two groups as follows: poor responders (NRO <8, n=40) and normoresponders (NRO=8-12, n=38). The mean age, body mass index (BMI), 3-day FSH, and estradiol levels of study population were 31.5±5.2 years, 24.9±5.3 kg/m2, 6.9±3.4 IU/mL and 40.4±16.6 pg/mL, respectively. In poor responders, the great extent of ET (67.5%) was performed at cleavage stage, but in normoresponders the majority of ET (86.8%) was performed at blastocyst stage (p<0.01). There was no significant difference between the groups for the parameters of grade1 embryo rate, fertilization rate, pregnancy rate, and implantation rate. Conclusion: Our results indicate that the poor responder patients with good grade cleavage stage embryo have no disadvantage in ICSI-ET cycles compared to normoresponders with blastocyst embryo. [ABSTRACT FROM AUTHOR]