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Self-Assembled Supramolecular Hetero-Bimetallacycles for Anticancer Potency by Intracellular Release.
- Source :
-
Chemistry - A European Journal . Oct2014, Vol. 20 Issue 44, p14410-14420. 11p. - Publication Year :
- 2014
-
Abstract
- Two new tetracationic hetero-bimetallacycles, compounds 4 and 5, have been constructed from an N, N′-bis(4-(pyridin-4-ylethynyl)phenyl)pyridine-2,6-dicarboxamide ligand ( 1), and cis-blocked complexes [M(dppf)(OTf)2] (dppf=1,1′-bis(diphenylphosphino)ferrocene; OTf=trifluoromethanesulfonate; M=Pd ( 2), Pt ( 3)) in CH3NO2/CH2Cl2 (1:1) solvent. Both complexes were isolated with adequate yields as triflate salts and were then characterized using 1H, 13C, and 31P NMR spectroscopy, elemental analysis, UV/Vis spectroscopy, and high-resolution electrospray mass spectrometry (HR-ESMS). The molecular structure of 4 was determined by molecular mechanics force-field calculations. The cytotoxic effect of both new complexes were analyzed against T98G (brain tumor), KB (head and neck cancer), SNU-80 (thyroid cancer), and HEK-293 non-malignant cell lines. The cytotoxicity of complexes 4 and 5 were found to be considerably more effective against cancer cells than reference drug cisplatin. Annexin-V/PI staining, caspase-3/7 activity, and the reduction in mitochondrial membrane potential justify a significant level of apoptosis in complex-treated cells. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09476539
- Volume :
- 20
- Issue :
- 44
- Database :
- Academic Search Index
- Journal :
- Chemistry - A European Journal
- Publication Type :
- Academic Journal
- Accession number :
- 98982162
- Full Text :
- https://doi.org/10.1002/chem.201403372