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trans-10, cis-12 Conjugated linoleic acid specifically increases tissue α-tocopherol mediated by PPARγ inhibition in mice.
- Source :
-
International Journal of Food Sciences & Nutrition . Nov2014, Vol. 65 Issue 7, p841-847. 7p. 4 Charts, 5 Graphs. - Publication Year :
- 2014
-
Abstract
- C57BL/6J mice were divided into control group (C), CLA, c9t11, or t10c12 groups. CLA and t10c12 significantly increased α-tocopherol levels in the plasma and various tissues in experiment 1. The CLA and t10c12 groups also showed a significant increase in hepatic α-tocopherol transfer protein (α-TTP) levels. In experiment 2, mice were divided into control, CLA, R (rosiglitazone, a PPARγ agonist), or CLA+R groups. Vitamin E levels in the liver, epididymal fat pad, kidney, and plasma were increased by CLA, and this effect was reduced in the CLA+R group. t10,c12-CLA is the most active isomer in the CLA mixture in the regulation of tissue vitamin E status and α-TTP protein levels in mice. The increase in liver vitamin E status in CLA-fed mice is mainly due to the effect of PPARγ inhibition. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09637486
- Volume :
- 65
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- International Journal of Food Sciences & Nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 98999758
- Full Text :
- https://doi.org/10.3109/09637486.2014.917150