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Study of MDM2 and SUMO-1 expression in actinic cheilitis and lip cancer.
- Source :
-
Archives of Dermatological Research . Nov2014, Vol. 306 Issue 9, p837-841. 5p. - Publication Year :
- 2014
-
Abstract
- Actinic cheilitis exhibits a potential of malignant transformation in 10-20 % of cases. The objective of this study was to compare the expression of MDM2 and SUMO-1 proteins between actinic cheilitis (AC) and squamous cell carcinoma (SCC) of the lip. The sample consisted of lower lip mucosa specimens obtained from cases with a clinical and histopathological diagnosis of AC ( n = 26) and SCC ( n = 25) and specimens of labial semi-mucosa ( n = 15) without clinical alterations or inflammation. The tissue samples were stained with hematoxylin-eosin and anti-MDM2 and anti-SUMO-1 antibodies. Data were analyzed by the Kruskal-Wallis and Dunn's tests (5 %). The median expression of MDM2 (kW = 36.8565; df = 3−1 = 2; p = 0.0001) and SUMO-1 (kW = 32.7080; df = 3−1 = 2; p = 0.0001) was similar in cases of AC and SCC of the lip, but differed significantly from that observed for normal labial semi-mucosa. Despite the limitations of the present study, immunohistochemistry demonstrated the overexpression of important proteins (MDM2 and SUMO-1) related to regulatory mechanisms of apoptosis in AC and SCC of the lip, but further studies are needed. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03403696
- Volume :
- 306
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Archives of Dermatological Research
- Publication Type :
- Academic Journal
- Accession number :
- 99000008
- Full Text :
- https://doi.org/10.1007/s00403-014-1500-8