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Protective effects of escin against indomethacin-induced gastric ulcer in mice.
- Source :
-
Toxicology Mechanisms & Methods . Dec2014, Vol. 24 Issue 8, p560-566. 7p. 1 Color Photograph, 5 Graphs. - Publication Year :
- 2014
-
Abstract
- Escin, a natural mixture of triterpenoid saponin isolated from the seed of the horse chestnut, is reported to have a potent antiulcer activity against ethanol-induced gastric mucosal lesions. This study investigated the possible mechanisms underlying the gastroprotective effect of escin against indomethacin-induced gastric ulcer in mice. Gastric ulceration was induced by a single intragastric administration of indomethacin (18 mg/kg). The mice underwent intragastric treatment with escin at doses of 0.45, 0.9 or 1.8 mg/kg. Gastric lesion was estimated morphometrically and histopathologically 6 h after the indomethacin administration. The antioxidative parameters in gastric mucosa were measured. Moreover, the activity of myeloperoxidase and the contents of TNF-α, P-selectin and VCAM-1 in gastric tissues were determined. The results showed that escin protected gastric tissues against indomethacin-induced gastropathy as demonstrated from a reduction in the ulcer index and an attenuation of histopathologic changes. Escin caused significant reductions of the contents of malondialdehyde, TNF-α, P-selectin, VCAM-1 and myeloperoxidase activity. The altered activities of superoxide dismutase, catalase and glutathione peroxidase in the stomach tissues were also ameliorated by escin treatment. The present study demonstrated that escin had a protective effect against indomethacin-induced gastric ulcer in mice, not only by virtue of its antioxidant potential, but also due to its anti-inflammatory effect. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15376516
- Volume :
- 24
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Toxicology Mechanisms & Methods
- Publication Type :
- Academic Journal
- Accession number :
- 99076150
- Full Text :
- https://doi.org/10.3109/15376516.2014.951815