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Negative regulation of peroxiredoxin 6 (Prdx 6) transcription by nuclear oncoprotein DEK during leukemia cell differentiation.
- Source :
-
Animal Cells & Systems . Oct2014, Vol. 18 Issue 5, p318-323. 6p. - Publication Year :
- 2014
-
Abstract
- The oncogene protein DEK is an abundant and ubiquitous nuclear protein with implications in acute myelogenous leukemia, as translocation which results in the formation of a DEK-CAN fusion protein. In a previous study, we have identified that DEK negatively regulated peroxiredoxin 6 (Prdx 6) transcription synergistically with the p65 subunit of NF-κB. In this study, we further investigated DEK-mediated transcriptional regulation of Prdx 6 during leukemia cell differentiation. Using Chromatin Immunoprecipitation analysis and Prdx 6 reporter assays, we found that DEK operated as a negative regulator of Prdx 6 transcription during leukemia cell differentiation. DEK was highly expressed and recruited to Prdx 6 promoter along with p65 and repressed transcription after leukemia cell differentiation. [ABSTRACT FROM PUBLISHER]
Details
- Language :
- English
- ISSN :
- 19768354
- Volume :
- 18
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Animal Cells & Systems
- Publication Type :
- Academic Journal
- Accession number :
- 99111569
- Full Text :
- https://doi.org/10.1080/19768354.2014.950605