Correlation of Osteoprotegerin, TGF-β1 and Glucose Metabolism Indicators in Type 2 Diabetes Patients with Coronary Heart Disease.

Objective To analyze the correlation of osteoprotegerin, TGF-β 1 and glucose metabolism indicators in type 2 diabetes patients with coronary heart disease. Methods 124 diabetes patients were divided into diabetic and coronary heart disease group (A), diabetic and non- CHD group (group B), there were 51 and 73 cases separately. 40 healthy people were selected as control group (group C). OPG, TGF-β 1, FPG, HbA1c, FINS and HOMA-IR were detected in each group. Results OPG and TGF-β 1 in Group B were significantly higher than that in group C (P < 0.05), OPG and TGF-β 1 in group A were significantly higher than group B, group C (P< 0.05) . FPG, HbA1c, FINS and HOMA-IR in Group B had significant difference with group C (P < 0.05). HbA1c, HOMA-IR in A group were significantly higher than B, C group (P < 0.05), FPG, FINS in A group were significantly higher than C group (P <0.05) .OPG and FPG, HbA1c, FINS and HOMA-IR were significantly positively correlated (P < 0.05), TGF-β 1 and HbA1c, HOMA-IR showed significant positive correlation (P < 0.05) . Conclusion High levels of TGF- β 1 and OPG are important factors leading to cardiovascular complications and are significantly correlated with HbA1c, HOMA-IR. [ABSTRACT FROM AUTHOR]