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Radiolabeled bioactive benzoheterocycles for imaging β-amyloid plaques in Alzheimer's disease.
- Source :
-
European Journal of Medicinal Chemistry . Nov2014, Vol. 87, p703-721. 19p. - Publication Year :
- 2014
-
Abstract
- Alzheimer's disease (AD) is a debilitating neurodegenerative dementia that involves substantial neuronal loss. Extracellular deposition of neurotoxic β -amyloid (A β ) plaques in the brain has been recognized as the central histological characteristic of AD. In the past decade, precise detection of the A β plaques at preclinical AD with positron emission tomography (PET) or single photon emission computed tomography (SPECT) has achieved continued development. A big category of A β imaging agents was benzoheterocycles which derived from Thioflavin-T (ThT), a traditional amyloid binding dye. This review summarizes the past and current status of radioactive benzoheterocycles designed to selectively bind to A β plaques. Separate sections discuss the chemical synthesis, in vitro and in vivo investigations of radiolabeled benzothiazole, benzoxazole, benzofuran, benzothiophene, indole, imidazopyridine and quinoxaline analogs to act as PET/SPECT candidates for imaging A β plaques. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 02235234
- Volume :
- 87
- Database :
- Academic Search Index
- Journal :
- European Journal of Medicinal Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 99250297
- Full Text :
- https://doi.org/10.1016/j.ejmech.2014.10.012