Cadmium(II) complex with 2-methyl-1H-4,5-imidazoledicarboxylic acid ligand: synthesis, characterization, and biological activity.

A coordination polymer, [Cd(L)2(H2O)2]n(HL = 2-methyl-1H-4,5-imidazoledicarboxylic acid), was prepared from reactions of Cd(NO3)2with L at room temperature. It was characterized by IR spectra and elemental analysis. The complex was structurally characterized by X-ray single-crystal diffraction revealing that the complex crystallizes in monoclinic withP2(1)/cspace group,a = 12.203(10) Å,b = 9.332(8) Å,c = 7.554(7) Å,β = 100.894(2) Å,V = 844.7(13) Å3,Z = 2. Fluorescence and UV absorption spectroscopy indicated that the complex can bind to fish sperm DNA. Gel electrophoresis assay demonstrated the ability to cleave the HL-60 plasmid DNA. Apoptotic study showed that the complex exhibited significant cancer cell (JEKO and KB) inhibitory rate. Complex binding to DNA in an intercalative mode [ABSTRACT FROM PUBLISHER]