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Effects of 1-mo bolus subcutaneous administration of exedin-4 in type 2 diabetes.
- Source :
-
American Journal of Physiology: Endocrinology & Metabolism . Jun2003, Vol. 47 Issue 6, pE1072. 8p. 2 Charts, 12 Graphs. - Publication Year :
- 2003
-
Abstract
- A gut insulinotropic peptide, glucagon-like peptide-1 (GLP-1), when given continuously subcutaneously, has been shown to be an effective agent to treat type 2 diabetes. Because of inactivation by dipeptidyl peptidase IV (DPP IV), it has a very short half-life (90-120 s), hence the need for continuous administration. Exendin-4 is an agonist of the GLP-1 receptor. It is not a substrate for DPP IV, and we previously demonstrated that intravenous administration has potent insulinotropic properties in type 2 diabetic volunteers. We evaluated the efficacy of bolus subcutaneous exendino4 in insulin-naive type 2 diabetic volunteers. Ten patients aged 44-72 yr with mean fasting glucose levels of 11.4 ± 0.9 mmol/l were enrolled, and daily or twice-daily bolus subcutaneous exendin-4 was selfadministered for i mo. Glycosylated hemoglobin, multiple daily capillary blood glucose, β-cell sensitivity to glucose, and peripheral tissue sensitivity to insulin were compared before and after treatment. The greatest decline in capillary blood glucose was seen before bed, with a drop from 15.5 to 9.2 mmol/l (P < 0.0001). Glycosylated hemoglobin improved significantly with treatment, from 9.1 to 8.3% (P = 0.009). β-Cell sensitivity to glucose was improved, as assessed by C-peptide levels during a hyperglycemic clamp. No significant adverse effects were noted or reported. Our data suggest that, even with this short duration of therapy, exendin-4 treatment had a significant effect on glucose homeostasis. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PEPTIDES
*TYPE 2 diabetes treatment
*CD26 antigen
Subjects
Details
- Language :
- English
- ISSN :
- 01931849
- Volume :
- 47
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- American Journal of Physiology: Endocrinology & Metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 9928454
- Full Text :
- https://doi.org/10.1152/ajpendo.00315.2002